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. Author manuscript; available in PMC: 2015 May 14.
Published in final edited form as: Nat Commun. 2014 Nov 14;5:5210. doi: 10.1038/ncomms6210

Figure 6. Model depicting the mechanisms of H3K4me3 loss in senescence.

Figure 6

The HUCA histone chaperone complex showing ASF1a/HIRA is depicted depositing H3.3, coupled to eviction of replication-dependent histone H3.1. Both JARID1A/1B-mediated demethylation and CTSL-mediated proteolytic processing of H3.3 tail act to prevent transcription of cell cycle-related genes via removal of H3K4me3. These processes may work together or independently to ensure the silencing of proliferation-promoting genes during cellular senescence.