Table 1.

Interactions of the pioneer transcription factor FoxA and the viral oncoprotein EBNA1 with epigenetic regulatory mechanisms.

Epigenetic mechanism	Phenomenon elicited by
	FoxA	EBNA1
DNA methylation	Demethylation	Demethylation
Histone acetylation	Upregulationhistone H3	?
Histone methylation	?	?
Polycomb/Trithorax complexes	?	?
Binding to mitotic chromosomes	“Bookmarking”?	“Bookmarking”?
Nucleosome rearrangement	Alteration of a hormone-dependent sub-nucleosome complex at the MMTV LTR	Nucleosome destabilization at oriP of EBV episomes
DNA looping	?	EBNA1-EBNA1 binding may link distinct DNA regions in viral and cellular genomes (epigenetic memory?)