Table 1.

A summary of autophagic alteration with aging of Ngsk PrP-deficient mouse line [32].

	3-4 months of age	6-8 months of age
PrP-deficient mice	LC3B, P62 and Lamp1 are increased Accumulation of autophagy features in axons and soma and dendrites	LC3B, P62 and Lamp1 are increased Scrg1 accumulates in Golgi apparatus Accumulation of autophagy in the axons, soma and dendrites Increased amount of autophagic degeneration