Table 1.

Comparison of disease signs between humans and mice following Omsk hemorrhagic fever virus infection.

Species	Human	Mouse
Incubation period	3–7 days (average)	5–8 days
Disease duration	8–14 days (up to 5 weeks in biphasic patients)	9–13 days
Biphasic	Yes	No
Disease signs	Fever, cephalalgia, cough, myalgia, dehydration, gastrointestinal symptoms, facial hyperemia, epistaxis, gingival and vaginal hemorrhage, hemorrhagic rash, hepatomegaly	Weight loss, piloerection, lethargy, hunched posture, conjunctival suffusion, neurological signs
Hematologic changes	Thrombocytopenia, leukopenia, neutrophilia, monocytosis	Leukopenia, neutrophilia
Pathologic changes	Respiratory tract, uterus, liver, GI tract	Brain, thymus, spleen, urinary tract, GI tract
Case fatality	0.4–2.5%	100%