Table 2.
Variable | Group | Dose | |||||
---|---|---|---|---|---|---|---|
placebo | caffeine 150 | caffeine 300 | d-amph 20 |
effect size |
|||
ARCI-PCAG | control | 3.87 | 3.62 | 3.52 | 3.64 | ||
(0.82) | (0.83) | (0.79) | (0.71) | ||||
cocaine | 1.95 | 1.83 | 2.95 | 2.43 | |||
(0.58) | (0.68) | (0.82) | (0.67) | ||||
ARCI-A * | control | 3.20 | 3.60 | 3.80 | 3.22 | 0.33 | |
(0.51) | (0.68) | (0.59) | (0.38) | ||||
cocaine | 3.30 | 3.39 | 3.19 | 3.69 | |||
(0.51) | (0.54) | (0.44) | (0.45) | ||||
ARCI-BG | control | 6.00 | 6.35 | 6.05 | 5.83 | ||
(0.39) | (0.56) | (0.57) | (0.36) | ||||
cocaine | 5.69 | 5.77 | 5.07 | 5.57 | |||
(0.34) | (0.37) | (0.61) | (0.51) | ||||
ARCI-MGB | control | 4.09 | 4.34 | 5.14 | 4.04 | ||
(1.26) | (1.31) | (1.37) | (1.28) | ||||
cocaine | 5.29 | 5.62 | 4.31 | 5.18 | |||
(1.13) | (1.23) | (0.96) | (1.00) | ||||
ARCI-LSD *** | control | 1.78 | 2.43 | 1.23 | 1.70 | 0.32 | |
(0.44) | (0.56) | (0.41) | (0.41) | ||||
cocaine | 0.89 | 0.48 | 1.05 | 0.98 | |||
(0.47) | (0.49) | (0.49) | (0.45) | ||||
VAS-depression | control | 0.10 | 0.10 | 0.41 | 0.10 | ||
(0.10) | (0.10) | (0.30) | (0.06) | ||||
cocaine | 1.05 | 0.62 | 1.96 | 1.10 | |||
(0.54) | (0.47) | (1.12) | (0.51) | ||||
VAS-fatigue | control | 3.85 | 3.00 | 3.44 | 3.60 | ||
(1.37) | (1.48) | (1.64) | (1.07) | ||||
cocaine | 0.68 | 0.54 | 1.69 | 1.17 | |||
(0.32) | (0.25) | (0.71) | (0.36) | ||||
VAS-tension | control | 1.05 | 1.60 | 1.62 | 1.53 | ||
(0.38) | (0.53) | (0.60) | (0.48) | ||||
cocaine | 1.63 | 0.96 | 2.38 | 1.88 | |||
(0.62) | (0.57) | (0.94) | (0.61) | ||||
VAS-vigor | control | 8.25 | 8.50 | 9.78 | 8.28 | ||
(2.06) | (1.92) | (1.98) | (2.01) | ||||
cocaine | 10.42 | 10.85 | 9.27 | 10.31 | |||
(1.54) | (1.59) | (1.60) | (1.33) | ||||
VAS-anxious | control | 10.15 | 10.45 | 8.50 | 11.68 | ||
(5.31) | (5.69) | (4.91) | (4.62) | ||||
cocaine | 19.64 | 21.35 | 25.27 | 21.71 | |||
(6.17) | (6.01) | (7.12) | (5.43) | ||||
VAS-elated *, ** | control | 8.65 | 9.85 | 13.65 | 10.43 | 0.30, 0.37 | |
(5.33) | (5.32) | (6.10) | (4.48) | ||||
cocaine | 25.99 | 32.54 | 21.65 | 25.71 | |||
(6.01) | (7.62) | (5.68) | (6.42) | ||||
DEQ- feel effects | control | 16.75 | 20.25 | 9.45 | 11.37 | ||
(7.58) | (6.31) | (4.97) | (4.93) | ||||
cocaine | 17.30 | 20.73 | 17.62 | 18.68 | |||
(5.80) | (5.95) | (5.91) | (6.08) | ||||
DEQ- like effects | control | 39.92 | 35.62 | 52.17 | 42.25 | ||
(6.82) | (6.89) | (6.95) | (5.74) | ||||
cocaine | 37.18 | 39.94 | 43.75 | 32.04 | |||
(9.74) | (10.55) | (7.21) | (8.63) | ||||
DEQ- high | control | 10.77 | 12.17 | 7.17 | 7.17 | ||
(5.23) | (5.59) | (4.16) | (3.95) | ||||
cocaine | 14.35 | 16.14 | 15.87 | 14.64 | |||
(5.45) | (5.67) | (5.78) | (5.44) | ||||
DEQ- like more | control | 25.77 | 25.62 | 32.92 | 25.65 | ||
(7.20) | (6.54) | (7.01) | (6.08) | ||||
cocaine | 25.96 | 25.68 | 28.71 | 26.16 | |||
(9.18) | (8.99) | (8.48) | (8.69) |
Means (delta-method robust standard errors) for subjective effects measures (ARCI, DEQ, VAS) across placebo, 150 mg caffeine, 300 mg caffeine, and 20 mg d-amphetamine doses. Data are averaged across two time points on each dose day, and shown separately for control and cocaine-dependent groups
p < .05, dose × time interaction, see text for details
p < .05, dose × group interaction, see text for details
p < .05, dose × group × time interaction, see text for details