Table 1.

Comparison of the models in terms of accuracy and speed. The first and third rows show the means and standard deviation (sd) of the graphical analysis reference tissue model (GARTM), the simplified reference tissue model (SRTM), the linearized-SRTM (SRTM_lin), a modified GARTM (GARTM_mod), a basis function model (BFM), and a “reduced” full reference tissue model (R-FRTM) for the medium sized particle simulations. The fourth row represents the time taken for the models to perform the fit for 10000 iterations. These results and their interpretations may vary for different particles and computers.

	GARTM	SRTM	SRTM_ lin	BFM	R-FRTM	GARTM_ mod
Estimated Receptor Concentration (Mean ± SD)	1.9 ± 0.1	2.0 ± 0.1	2.1 ± 0.1	1.9 ± 0.0	2.1 ± 0.1	1.1 ± 0.0
Error in receptor concentration estimate	−0.06	0.04	0.06	−0.12	0.08	−0.89
Elapsed Time for 10,000 fits (s)	13	240	5	103	838	25