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Effect of modification and targeting of various drug delivery vehicles for treatment of brain injury. Upper graph shows a significantly decreased infarct volume after treatment with PBCA nanoparticles modified with SOD and a further decrease when these particles were targeted with NR1 antibody on the particle surface. In the lower graph, a similar trend was observed with liposomes (lipo), poly(lactic acid) (PLA) nanoparticles, and PLGA nanoparticles with bulk loaded SOD.102
