Table 2.
Carcinogenicity of the aspartame in animal models
| Test material | Carcinogenicity model | Results | References |
|---|---|---|---|
| 860 SCL Wistar rats | Brain tumor | − | Ishii (1981) |
| Male F344 rats | Brain and bladder tumors | − | Hagiwara et al. (1984) |
| Rat | Brain, prostate and breast tumors | + | Olney et al. (1996) and Schwartz (1999) |
| Sprague–Dawley male and female rats | Lymphoma, leukemia | + | Soffritti et al. (2006) |
| Sprague–Dawley female rats | Transitional cell carcinoma of the renal pelvis and ureter | + | Soffritti et al. (2006) |
| Sprague–Dawley male rats | Malignant schwannomas of peripheral nerve | + | Soffritti et al. (2006) |
+ Positive, − negative