Table 3.
Carcinogenicity of the aspartame in epidemiological studies
| Study design | Carcinogenicity model | Results | References |
|---|---|---|---|
| Human | Brain tumor | + | Olney et al. (1996) |
| Children (56 patients and 94 controls) | Brain tumor | − | Gurney et al. (1997) |
| 88,794 Women and 49,364 men (379 cases) | Pancreatic cancer | − | Schernhammer et al. (2005) |
| 285,079 Men and 188,905 women (1,888 hematopoietic cancers and 315 malignant gliomas) | Hematopoietic cancer and malignant glioma | − | Lim et al. (2006) |
| 197 Patients and 397 controls | Urinary tract tumors | + | Andreatta et al. (2008) |
| 230 Patients and 547 controls (stomach), 326 patients and 652 controls (pancreas), 454 patients and 908 controls (endometrium) | Stomach, pancreas and endometrium cancers | − | Bosetti et al. (2009) |
| 1,324 Non-Hodgkin lymphomas (NHLs), 285 multiple myelomas, and 339 leukemias | Non-Hodgkin lymphomas, multiple myelomas, leukemias | − (Woman) + (Men) |
Schernhammer et al. (2012) |
+ Positive, − negative