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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Curr Transplant Rep. 2014 May 24;1(3):137–146. doi: 10.1007/s40472-014-0018-5

Figure 1.

Figure 1

Repertoires of donor-reactive memory T cells in unprimed vs. donor-antigen primed individuals. A hypothetical representation of the endogenous memory T cell repertoire (blue) within (A) unmanipulated animals and (B) following priming by strategies typically used to induce high numbers of donor-reactive memory T cells. While such priming approaches certainly expand the population of memory T cells reactive to donor-MHC (green), it is likely that the frequency of strongly donor-reactive memory T cells (ie, those with high affinity TCRs for donor antigen) (red) is also significantly increased.