. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Curr Transplant Rep. 2014 May 24;1(3):137–146. doi: 10.1007/s40472-014-0018-5

Table 1.

Characteristics of memory versus naïve T cells

Cell Type	Naïve T Cell	Central Memory T Cell	Effector Memory T Cell
Phenotype (human)	CD45RA^hiCD45RO^low CD62L^hiCCR7^hi	CD45RA^lowCD45RO^hi CD62L^hiCCR7^hi	CD45RA^lowCD45RO^hi CD62L^lowCCR7^low
Phenotype (mouse)	CD44^low CD62L^hiCCR7^hi	CD44^hiCD62L^hiCCR7^hi	CD44^hiCD62L^lowCCR7^low
Location	Spleen, lymph nodes	Spleen, lymph nodes, bone marrow	Spleen, blood, peripheral tissues
Response Time After Antigen	Days	Hours	Hours
Costimulation Requirements	+++	−/+	−/+
Proliferative Potential	−	+++	++
Cytokine Production	−	+++ (IL-2)	+++ (IFN-γ, TNF-α)
Effector Functions/ Cytotoxicity	−	+	+++
Sensitivity to Immuno-suppression	+++	−/+	−/+