Table 3. Validation Criteria for Endometrial Carcinoma Data.

Normal VAF	Tumor VAF
	0%	<8%	≥8%, <20%	≥20%
= 0%	Not Validated	Somatic Low	Somatic Med	Somatic High
<3%	Not Validated	Ambiguous	Somatic Med	Somatic High
≥3%	Germline/LOH	Germline/LOH	Germline/LOH	Germline/LOH

Validation BAMs were used to determine the validation status for somatic mutations as shown here. A mutation is considered validated in the Somatic Low, Med, or High groups (bold), not validated in the “Not Validated” (italics) and Germline/LOH groups (italics), and Ambiguous when there was low read depth (<10 reads) or low VAFs in both the normal (<3%) and tumor (<8%) validation BAMs.