Table 1. Pharmacokinetic properties of Compound A and Compound B in mice.
| Compound A | Compound B | |
| T max (h) | 1 | 1 |
| C max in plasma (µM) | 240±59 | 9.1±2.3 |
| plasma/IC50 | 38±9.2 | 0.59±0.15 |
| C max in skin (µmol/kg) | 14±0.62 | 1.3±0.51 |
| skin/IC50 | 2.2±0.097 | 0.084±0.033 |
| C max in intestine (µmol/kg) | 77±37 | 92±36 |
| intestine/IC50 | 12±5.8 | 5.9±2.3 |
| C 24 in intestine (µmol/kg) | 24±1.6 | 19±3.7 |
| C 24 in intestine/mDGAT1 IC50 | 3.7±0.24 | 1.2±0.24 |
| Intestine/Plasma ratio at T max | 0.32±0.090 | 10±2.8 |
| Intestine/Skin ratio at T max | 5.6±2.5 | 74±8.4 |
plasma/IC50 = C max in plasma/mDGAT1 IC50, skin/IC50 = C max in skin/mDGAT1 IC50, intestine/IC50 = C max in intestine/mDGAT1 IC50, Three mice were used in each group. Data were expressed as means ± SD.