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. 2014 Nov 18;9(11):e112027. doi: 10.1371/journal.pone.0112027

Table 2. Summary of the effects of Compound A and Compound B.

Compound A Compound B
mDGAT1 IC50 a 6.4 nM 15.5 nM
hDGAT1 IC50 a 2.6 nM 8.4 nM
Log D <0.9 <0.9
m plasma protein binding 3.2% free 0.1% free
a

The 50% inhibitory concentration (IC50) for each compound in the enzymes expressed in insect microsomes.