Table 2. Summary of the effects of Compound A and Compound B.
Compound A | Compound B | |
mDGAT1 IC50 a | 6.4 nM | 15.5 nM |
hDGAT1 IC50 a | 2.6 nM | 8.4 nM |
Log D | <0.9 | <0.9 |
m plasma protein binding | 3.2% free | 0.1% free |
The 50% inhibitory concentration (IC50) for each compound in the enzymes expressed in insect microsomes.