Table 3. Multivariable analysis results for disease free survival (phase I; n = 236).

Variables	p-value	HR	95% CI (lower)	95% CI (upper)
LOX rs10519694 (CT+TT vs CC)	0.113	0.767	0.552	1.065
HIF2A rs11125070 (AT+TT vs AA)	0.004	0.619	0.446	0.859
Age	<0.001	1.034	1.019	1.048
Grade (poorly differentiated/undifferentiated vs well/moderately differentiated)	0.099	1.437	0.934	2.213
Stage	<0.001
Stage (II vs I)	0.112	1.553	0.903	2.673
Stage (III vs I)	<0.001	2.93	1.684	5.095
Stage (IV vs I)	<0.001	133.705	55.984	319.324
MSI status (MSI-H vs MSS/MSI-L)	0.013	0.4	0.194	0.825

CI: confidence interval, HR: hazard ratio, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable, n: number of patients. Significant associations (p<0.05) are shown in bold.