Table 5. Multivariable analysis results for overall survival (phase II; n = 477).
| 95% CI for HR | ||||
| Variables | p-value | HR | (lower) | (upper) |
| HIF2A rs4953352 (TC+CC vs TT) | <0.001 | 2.189 | 1.468 | 3.265 |
| HIF2B rs12593988 (GA+AA vs GG) | 0.009 | 0.627 | 0.442 | 0.890 |
| Sex (male vs female) | 0.116 | 1.310 | 0.936 | 1.834 |
| Stage | <0.001 | |||
| Stage (II vs I) | 0.166 | 1.491 | 0.847 | 2.623 |
| Stage (III vs I) | 0.039 | 1.846 | 1.033 | 3.299 |
| Stage (IV vs I) | <0.001 | 9.746 | 5.287 | 17.965 |
| Vascular invasion (+ vs −) | 0.179 | 1.257 | 0.901 | 1.755 |
| MSI status (MSI-H vs MSS/MSI-L) | 0.002 | 0.270 | 0.118 | 0.616 |
(+): present, (−): absent, CI: confidence interval, HR: hazard ratio, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable. Significant associations (p<0.05) are shown in bold.