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. 2014 Nov 18;9(11):e113421. doi: 10.1371/journal.pone.0113421

Figure 9. Vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) expression is reduced in the human post-mortem alcoholic basal forebrain.

Figure 9

(A) Western blot assessment of VAChT protein expression revealed a significant 30% (±7%) reduction in the alcoholic basal forebrain, relative to moderate drinking controls. Representative lanes from Western blot analysis of VAChT. CON is moderate drinking controls and ALC is alcoholic subjects. Western blot analyses were run in triplicate and the mean was reported. (B) ELISA revealed a significant 51% (±11%) reduction of ChAT in the basal forebrain of human alcoholics, relative to moderate drinking controls. Data are presented as mean ± SEM. * indicates p<0.05, relative to CONs.