Table 2. Primary and secondary outcomes.

Outcome	SOS(15 practices; n = 4234 patients)	Usual Care(15 practices; n = 3352 patients)	ICC	Planned analysis		Age & sex adjusted
				Treatment effect(95% CI)	P-value	Treatment effect(95% CI)	P-value
Cholesterol target achieved	2942 (69.5%)	2130 (63.5%)	0.005	1.11 (1.00, 1.23)	0.043	1.12 (1.01, 1.25)	0.027
Prescribed simvastatin 40 mg and targetcholesterol achieved	1898 (44.8%)	935 (27.9%)	0.024	1.78 (1.61, 1.98)	<0.001	1.81 (1.63, 2.01)	<0.001
Cholesterol level (mmol/l)*	4.22	4.36	0.038	0.98 (0.97, 0.99)	0.004	0.98 (0.97, 1.00)	0.006
Prescribed simvastatin 40 mg	2497 (59.0%)	1267 (37.8%)	0.025	2.06 (1.87, 2.28)	<0.001	2.12 (1.92, 2.34)	<0.001
Prescribed any statin	3682 (87.0%)	2509 (74.9%)	0.014	1.82 (1.60, 2.06)	<0.001	1.87 (1.65, 2.13)	<0.001
Cholesterol tested	3892 (91.9%)	2945 (87.9%)	0.050	1.30 (1.11, 1.54)	0.002	1.33 (1.13, 1.57)	<0.001

For binary outcomes, summaries are presented as number (percent) and treatment effects as odds ratios (SOS vs Usual Care) with corresponding 95% confidence intervals estimated from logistic regression models, adjusted for matched pairs. For continuous outcomes (*), summaries are presented as geometric means and treatment effects are presented as ratios (SOS vs Usual Care) with corresponding 95% confidence intervals estimated from linear regression models of the logged values, adjusted for matched pairs.