Table 2.
Plasma metabolite concentrations of obese versus lean children
Metabolite concentration z-score | ||||
---|---|---|---|---|
Factor loading | Obese | Lean | Pb | |
BMI ≥95th %ile n = 84 |
BMI <85th %ile n = 150 |
|||
|
||||
Factor 4: mean ± SD = 0.00 ± 1.52 | ||||
Valine | 0.83 | 1.17 ± 2.75 | −0.54 ± 2.47 | <0.0001 |
Leucine | 0.76 | 1.38 ± 2.93 | −0.37 ± 2.66 | <0.0001 |
Phenylalanine | 0.72 | 1.23 ± 3.02 | −0.27 ± 2.66 | <0.0001 |
Isoleucine | 0.71 | 1.18 ± 2.84 | −0.37 ± 2.47 | <0.0001 |
Propionylcarnitine (C3) | 0.66 | 0.95 ± 2.66 | −0.44 ± 2.29 | <0.0001 |
2-methylbutyrylcarnitine (C5) | 0.63 | 0.80 ± 2.66 | −0.03 ± 2.38 | 0.0002 |
Isovalerylcarnitine | 0.60 | 1.34 ± 2.75 | −0.33 ± 2.38 | <0.0001 |
Isobutyrylcarnitine | 0.56 | 1.19 ± 3.21 | 0.33 ± 2.84 | 0.001 |
Tryptophan | 0.54 | 1.07 ± 3.02 | 0.21 ± 2.66 | 0.0007 |
3-methyl-2-oxovalerate (KMV) | 0.52 | 0.92 ± 2.75 | −0.11 ± 2.38 | <0.0001 |
Kynurenine | 0.52 | 0.56 ± 2.93 | −0.19 ± 2.57 | 0.002 |
Tyrosine | 0.51 | 1.54 ± 2.57 | 0.04 ± 2.29 | <0.0001 |
Gamma-glutamylleucine | 0.51 | 0.53 ± 2.93 | −0.23 ± 2.57 | 0.002 |
4-methyl-2-oxopentanoate (KIC) | 0.51 | 0.73 ± 2.75 | −0.23 ± 2.38 | <0.0001 |
Factor 9: mean ± SD: 0.00 ± 1.62 | ||||
4-androsten-3beta,17beta-diol disulfate 1* | 0.86 | 0.61 ± 2.84 | −0.49 ± 2.47 | <0.0001 |
Dehydroepiandrosterone sulfate (DHEA-S) | 0.84 | 0.45 ± 2.47 | −0.41 ± 2.11 | <0.0001 |
Epiandrosterone sulfate | 0.79 | 0.14 ± 2.93 | −0.70 ± 2.66 | 0.0007 |
Androsterone sulfate | 0.79 | 0.30 ± 2.66 | −0.38 ± 2.38 | 0.002 |
4-androsten-3beta,17beta-diol disulfate 2* | 0.78 | 0.48 ± 3.21 | −0.74 ± 2.84 | <0.0001 |
Pregn steroid monosulfate* | 0.76 | 0.70 ± 2.75 | −0.22 ± 2.38 | <0.0001 |
Pregnen-diol disulfate* | 0.70 | 0.30 ± 2.75 | −0.14 ± 2.38 | 0.05 |
Pregnenolone sulfate | 0.65 | 0.71 ± 3.02 | −0.09 ± 2.66 | 0.002 |
Andro steroid monosulfate 2* | 0.61 | 0.41 ± 2.66 | −0.46 ± 2.38 | <0.0001 |
Estimates represent mean ± SD and are adjusted for child’s sex, age, and race/ethnicity.
From the Wald test.
Indicates tier 2 identification in which no commercially available authentic standards could be found, however annotated based on accurate mass, spectral and chromatographic similarity to tier 1 identified compounds.