Figure 4.
Schematic representation comparing mice receiving only 17β-estradiol (represented by mouse with ‘E’ on abdomen) to those receiving testosterone (represented by mouse with ‘T’ on abdomen) after surgical gonadectomy. Three scenarios (panels a–c) exist regarding testosterone’s conversion and lead to three possible wheel running responses if the estrogens are the primary effecters of activity (panels d–f) and three possible responses if an androgenic effect is also present (panels g–i). T=Testosterone, E=17β-estradiol, dotted outline=observed outcome from present dataset.