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Activation of the DmOctβ1R in hippocampal neurons leads to increased cAMP levels selectively in the hippocampus. A, A systemic injection with octopamine (1 mg/kg) increased hippocampal cAMP levels 30 min after injection (*p = 0.034, t test) in mice expressing DmOctβ1R. B, Systemic injection with octopamine (1 mg/kg) did not alter cAMP levels in the prefrontal cortex 30 min after injection in mice expressing DmOctβ1R (p = 0.668, t test). All data are expressed as the mean ± SEM.
