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. 2014 Nov 14;12:71. doi: 10.1186/s12964-014-0071-9

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© Li et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Genetic deletion of PTP1B mimics the effects of depleting Nck1 on Akt phosphorylation and pY protein levels. (A) Total cell lysates prepared from PTP1B ^+/+ and PTP1B ^−/− MEFs were subjected to immunoblot with indicated antibodies. Data are representative of three independent experiments showing similar results. (B) PTP1B ^+/+ and PTP1B ^−/− MEFs were treated with or without 100 μM of PV for 5 min before harvesting. Total cell lysates were subjected to immunoblot with indicated antibodies. Data are representative of three independent experiments performed in triplicate and showing similar results.