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. 2014 Nov 11;2:147. doi: 10.1186/s40478-014-0147-1

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© Molas et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Short-term novel object recognition memory. (a) Drug administration protocol used during the novel object recognition (NOR) task (Hab, Habituation session; Fam, Familiarization session; Test session). (b) Saline (Sal)-treated TgCHRNA5/A3/B4 (Tg) mice presented a significant impairment in recognition memory, as compared to wild type (WT) littermates, as shown by reduced discrimination index which was expressed as [(time exploring the novel object – time exploring the familiar object)/total time of exploration*100]. Chronic administration of nicotine (Nic, 3.25 mg/kg/d) for 5 d rescued the impaired recognition memory in Tg mice, but had no effect in WT (n = 10–12 animals/group from ≥ 3 experiments). *p ≤ 0.05, **p ≤ 0.01.