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. 2014 Aug 19;14:148. doi: 10.1186/1471-230X-14-148

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Copyright © 2014 Steinebrunner et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cholinesterase inhibition protects against acute liver failure (ALF) induced by acetaminophen (APAP). All mice received 600 mg/kg APAP i.p.. Neostigmine-treated animals received 80 μg/kg neostigmine 1 hour prior to application of APAP and 7, 12 and 24 hours thereafter (dotted line, p_log-rank = 0.0046) or 1, 7, 12 and 24 hours after application of APAP (dashed line, p_log-rank = 0.1860). Control mice received solvent (0.9% NaCl) 1, 7, 12 and 24 hours after application of APAP (solid line; n = 6 for each group).