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. 2014 Aug 19;14:148. doi: 10.1186/1471-230X-14-148

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Copyright © 2014 Steinebrunner et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Administration of neostigmine reduces serum cytokine levels. 12 h after induction of acute liver failure by acetaminophen (600 mg/kg APAP i.p.), serum was collected from neostigmine-treated (80 μg/kg, 1 and 7 hours after application of APAP) and control mice. Cytokine concentrations of (A) IL-1β and (B) TNF-α were measured by enzyme-linked immunosorbent assay (mean ± SD; open bars, control mice, hatched bars, APAP + solvent, filled bars, APAP + neostigmine; n = 6 for each group; *p < 0.05, **p < 0.01 APAP-alone-treated mice vs. APAP + neostigmine-treated mice).