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. 2014 Aug 1;14:206. doi: 10.1186/s12866-014-0206-6

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Copyright © 2014 Chen et al.; licensee BioMed Central Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Diagram of BsaN regulon. The BsaN regulon is shown as part of a regulatory network, which is superseded by BprP activating transcriptions of T3SS3 apparatus genes (blue) including bsaN. The bicA gene is likely initially transcribed via read through of apparatus genes. BsaN-BicA function as a complex to activate T3SS3 translocon (purple), effector (yellow), accessory (grey) and regulatory (red) genes. Transcriptional activation is indicated by green arrows. BsaN-BicA also activate virAG, which in turn activates the bimA motility genes and the T6SS1 locus. BprC activates the T6SS1 tssAB apparatus genes. BsaN-BicA also activate a non-ribosomal polyketide synthesis locus and several metabolic genes. BsaN-repressed genes as indicated by red, blunted lines include T3SS3 apparatus genes and flagellar motility genes. Only genes which have been validated by qRT-PCR are shown.