Table 2.

Oral eradication-phase therapy for melioidosis.^a

Drug	Patient characteristics	Recommended dosage/frequency
Trimethoprim/sulfamethoxazole (co-trimoxazole)b	Adult, >60 kg	160 mg/800 mg tablets; two tablets every 12 h
	Adult, 40–60 kg	80 mg/400 mg tablets; three tablets every 12 h
	Adult, <40 kg	160 mg/800 mg tablets; one tablet every 12 h OR
		80 mg/400 mg tablets; two tablets every 12 h
	Child	8 mg/40 mg per kg; maximum dose 320 mg/1600 mg every 12 h
OR
Amoxicillin/clavulanic acid (co-amoxiclav)	Adult, >60 kg	500 mg/125 mg tablets; three tablets every 8 h c
	Adult, <60 kg	500 mg/125 mg tablets; two tablets every 8 h c
	Child	20 mg/5 mg per kg every 8 h; maximum dose 1000 mg/250 mg every 8 h

^aRecommended duration of therapy is a minimum of 12 weeks.

^bIf the organism is susceptible and the patient does not have a documented allergy to it, oral co-trimoxazole is the agent of first choice. If the organism is resistant to co-trimoxazole or the patient is intolerant, the second-line choice is co-amoxiclav. Co-amoxiclav is available in different ratios and formulations depending on the source country. Co-amoxiclav at a ratio of 4:1 is preferred to ensure there is sufficient clavulanic acid [20].

^cWeight-based dosage based on 20 mg/5 mg per kg per dose.

Adapted from [16] with permission.