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Minimal adequate genetic model of G6PD activity
| SNP | Allelic ES (95% CI) | % change |
|---|---|---|
| c.202 |
-0.198 (-0.213 - -0.183) |
-37.9 |
| rs2230037 (H+) |
+0.022 (+0.011 - +0.034) |
4.3 |
| c.376 (H-) | -0.017 (-0.030 - -0.005) | -3.3 |
A linear model containing both c.202G>A as well as SNPs tagging the H+ (rs2230037) and H- (c.376A>G) haplotypes explained significantly more variance than a model containing c.202G>A alone (P<0.001), and could not be improved via the inclusion of additional SNPs.
