Table 1.
Correlation of B7-H3 expression in breast cancer cells and Foxp3-positive cells in TILs with clinicopathologic features in 90 patients
| Clinical parameters | No. of cases | Foxp3-positive cell/TIL | B7-H3 expression | ||||
|---|---|---|---|---|---|---|---|
| Low (%) | High (%) | p valuea | Low (%) | High (%) | p valuea | ||
| Age (years) | |||||||
| ≤50 | 38 | 21 (23.3) | 17 (18.9) | 0.673 | 12 (13.3) | 26 (28.9) | 0.641 |
| >50 | 52 | 26 (28.9) | 26 (28.9) | 26 (28.9) | 26 (28.9) | ||
| Tumor size (cm) | |||||||
| ≤2 | 40 | 28 (31.1) | 12 (13.3) | 0.003 | 17 (18.9) | 23 (25.6) | 1.000 |
| >2 | 50 | 19 (21.1) | 31 (34.4) | 21 (23.3) | 29 (32.2) | ||
| Nodal metastasis | |||||||
| Without | 49 | 37 (41.1) | 21 (13.3) | <0.001 | 23 (25.6) | 26 (28.9) | 0.393 |
| With | 41 | 10 (11.1) | 31 (34.4) | 15 (16.7) | 26 (28.9) | ||
| Hormone receptor | |||||||
| Positive | 73 | 41 (45.6) | 32 (35.6) | 0.178 | 28 (31.1) | 45 (50.0) | 0.173 |
| Negative | 17 | 6 (6.7) | 11 (12.2) | 10 (11.1) | 7 (7.8) | ||
| HER2 | |||||||
| Positive | 40 | 13 (14.4) | 27 (30.0) | 0.001 | 18 (20.0) | 22 (24.4) | 0.672 |
| Negative | 50 | 34 (37.8) | 16 (17.8) | 20 (22.2) | 30 (33.3) | ||
| Nuclear grade | |||||||
| Low (0,1) | 34 | 25 (27.8) | 9 (10.0) | 0.002 | 17 (18.9) | 17 (18.9) | 0.277 |
| High (2,3) | 56 | 22 (24.4) | 34 (37.8) | 21 (23.3) | 35 (38.9) | ||
| Vascular invasion | |||||||
| Positive | 58 | 32 (35.6) | 26 (28.9) | 0.451 | 24 (26.7) | 34 (37.8) | 0.828 |
| Negative | 32 | 15 (16.7) | 17 (18.9) | 14 (15.6) | 18 (20.0) | ||
p values less than 0.05 are in bold
Foxp3 forkhead box P3, TILs tumor-infiltrating lymphocytes, HER2 human epidermal growth factor receptor 2
aChi-square analysis