Table 2.
Blood and urine biochemical examinations at 12 weeks
| Control group | Type 1 DN group | Type 2 DN group | |
|---|---|---|---|
|
Kidney weight (g) |
9.6 ± 1.42 |
10.07 ± 2.29* |
10.51 ± 2.38* |
|
Blood glucose (mmol/L) |
4.77 ± 1.13 |
23.37 ± 6.72* |
22.66 ± 5.00* |
|
SCr (μmol/L) |
56.24 ± 11.53 |
169.00 ± 12.08* |
155.20 ± 13.27* |
|
BUN (mmol/L) |
4.28 ± 0.53 |
9.82 ± 0.76* |
9.88 ± 0.69* |
|
Urinary microalbumin (mg/L) |
6.51 ± 1.38 |
21.71 ± 3.72* |
21.39 ± 3.17* |
|
Fasting insulin (μIU/mL) |
7.61 ± 2.31 |
1.25 ± 1.37* |
32.65 ± 2.56* |
|
GAD-Ab† |
− |
+ |
− |
| IAA† | − | + | − |
Abbreviations:DN diabetic nephropathy, SCr serum creatinine, BUN blood urea nitrogen, GAD-Ab glutamic acid decarboxylase autoantibody, IAA insulin autoantibody.
Normal ranges: blood glucose, 3.61–6.11 mmol/L; SCr, 44–133 μmol/L; BUN, 3.2–7.1 mmol/L; urinary microalbumin, <10 mg/L; fasting insulin, 5.8–18.6 μIU/mL.
Values are means ± standard deviation.
*P < 0.05 vs. control group.
There were no significant difference between types 1 and 2 diabetic nephropathy in terms of blood glucose, SCr, BUN, and urinary microalbumin results.
†Positivity for GAD-Ab and IAA is indicative of type 1 diabetes.