Figure 2.

Comparative in vivo efficacy of drugs against HVP2 and BV. Groups of mice were infected with virus on day 0 and observed for neurologic symptoms through day 14 after infection. Drugs were administered for 7 d, beginning 1 d prior to infection. Untreated (no drug) control groups are indicated by a heavy solid line. Drug and doses (mg/kg daily) tested were ACV (150, dashed line; 100, dotted line); PCV (200, solid line; 100, dashed line; 50, dotted line); EDU (400, dashed line; 200, dotted line); GCV (100, solid line; 50 dashed line; 25, dotted line); and CDV (200, 100, and 50: solid lines; 25, large dashed line; 12.5, medium dashed line; 6.25, small dashed line; 3.1, dotted line; 1.6, thin solid line).