Figure 1.

Effects of 20 weeks of treadmill exercise training on behavioral functions: (a) spontaneous alternation behavior; (b) total number of arm entries; (c) retention latency time. SED-Wt: sedentary wild-type mice. EXE-Wt: exercise-trained wild-type mice. SED-Tg: sedentary APP/PS1 transgenic mice. EXE-Tg: exercise-trained APP/PS1 transgenic mice. n = 32 for all independent experiments. Data are mean ± SD. ^** P < 0.01, compared to SED-WT group. ^# P < 0.05; ^## P < 0.01, compared to SED-Wt or SED-Tg group. n.s., nonsignificant.