Table 1.
Associations of miR-15a and/or miR-16 expression with the clinicopathological characteristics of colorectal cancer.
| Clinical features | Case number (%) | miR-15a-low | miR-16-low | miR-15a-low/miR-16-low | |||
|---|---|---|---|---|---|---|---|
| (N, %) | P | (N, %) | P | (N, %) | P | ||
| Gender | |||||||
| Male | 76 (60.32) | 42 (55.26) | NS | 45 (59.21) | NS | 32 (42.11) | NS |
| Female | 50 (39.68) | 31 (62.00) | 31 (62.00) | 21 (42.00) | |||
| Age (years) | |||||||
| <66 | 48 (30.10) | 32 (66.67) | NS | 32 (66.67) | NS | 22 (45.83) | NS |
| ≥66 | 78 (69.90) | 41 (52.56) | 44 (56.41) | 31 (39.74) | |||
| Site of primary tumor | |||||||
| Right-sided | 48 (38.10) | 30 (62.50) | NS | 30 (62.50) | NS | 22 (45.83) | NS |
| Left-sided | 46 (36.51) | 26 (56.52) | 26 (56.52) | 20 (43.48) | |||
| Rectum | 32 (25.40) | 17 (53.13) | 20 (62.50) | 11 (34.38) | |||
| Tumor size (cm) | |||||||
| <5 | 70 (55.56) | 42 (60.00) | NS | 42 (60.00) | NS | 32 (45.71) | NS |
| ≥5 | 56 (44.44) | 31 (55.36) | 34 (60.71) | 21 (37.50) | |||
| Depth of tumor invasion | |||||||
| T1-T2 | 47 (37.30) | 30 (63.83) | NS | 30 (63.83) | NS | 20 (42.55) | NS |
| T3-T4 | 79 (62.70) | 43 (54.43) | 46 (58.23) | 33 (41.77) | |||
| Lymph node metastasis | |||||||
| Negative | 68 (53.97) | 29 (42.65) | 0.01 | 29 (42.65) | 0.01 | 13 (19.12) | 0.008 |
| Positive | 58 (46.03) | 44 (75.86) | 47 (81.03) | 40 (68.97) | |||
| TNM stage | |||||||
| I | 13 (10.32) | 3 (23.08) | 0.001 | 3 (23.08) | 0.001 | 0 (0) | <0.001 |
| II | 46 (36.51) | 17 (36.96) | 20 (43.48) | 10 (18.87) | |||
| III | 50 (39.68) | 36 (72.00) | 36 (72.00) | 26 (52.00) | |||
| IV | 17 (13.49) | 17 (100.00) | 17 (100.00) | 17 (100.00) | |||
| Histological grade | |||||||
| Well/moderately | 80 (63.49) | 40 (50.00) | 0.02 | 40 (50.00) | 0.02 | 23 (28.75) | 0.01 |
| Poorly | 46 (36.51) | 33 (71.74) | 36 (78.26) | 30 (65.22) | |||
Note: “NS” refers to the difference without statistical significance.