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. Author manuscript; available in PMC: 2014 Nov 19.
Published in final edited form as: Nature. 2014 Jan 22;506(7487):179–184. doi: 10.1038/nature12929

Extended Data Figure 3. De novo mutation counts and rates.

Extended Data Figure 3

a. The observed distribution of number of validated RefSeq-coding (see Supplementary Text) de novo mutations found for each trio (N=617) is compared with that expected from a Poisson distribution with a rate equal to the observed mean number of de novos (λ=1.032).

b. Deleterious mutation rate inversely correlates with academic performance. Individuals were grouped according to their final school grade (3-6, corresponding to D, C, B, A in the US system, http://www.fulbright.bg/en/p-Educational-System-of-Bulgaria-18/), and the proportion of individuals with one or more de novo loss-of-function (LoF) mutations is plotted. See Supplementary Text for details on linear regression performed to evaluate association; note that 19 samples were removed from this analysis for missing parental age or school grade information, leaving a total of 598 trios.