Extended Data Table 4b.

Enrichment of de novo mutations (as calculated by dnenrich, see Supplementary Text) based on RNA-seq-based brain expression and developmental trajectory. Number and significance of overlap of mutations in schizophrenia, autism, and intellectual disability in genes not expressed in the brain, highly expressed in the brain, or with a pre- or postnatal expression bias in the brain (rows), based on BrainSpan RNA-seq data (see Supplementary Text). Columns are as in Table 2, and p<0.05 are marked in bold.

	Mutations	Current study				SZ (Gulsuner)14				SZ (Xu)13				ASD6-9				ID10,11
		NS (482)		LoF (64)		NS (68)		LoF (12)		NS (137)		LoF (20)		NS (789)		LoF (134)		NS (141)		LoF (34)
Brain expression?	# of genes	p	# mut	p	# mut	p	# mut	p	# mut	p	# mut	p	# mut	p	# mut	p	# mut	p	# mut	p	# mut
Low	5851	0.89	118	0.97	11	0.48	19	0.17	5	0.31	40	0.44	6	0.99	185	1	22	1	23	1	2
High	9279	0.0058	264	0.016	40	0.45	34	0.57	6	0.12	74	0.34	11	2.00E-05	442	0.00018	86	6.00E-05	93	0.0007	26
Pre-natal	7962	0.33	225	0.39	32	0.74	29	0.97	3	0.2	68	0.65	9	0.00054	405	0.00024	83	0.35	67	0.21	19
Post-natal	2393	0.17	64	0.54	7	0.68	7	0.74	1	0.96	10	0.65	2	0.95	79	0.88	11	0.71	15	0.89	2