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. Author manuscript; available in PMC: 2014 Nov 19.
Published in final edited form as: Chem Soc Rev. 2014 Oct 7;43(19):6716–6726. doi: 10.1039/c3cs60448a

Fig. 2.

Fig. 2

Chemical optimization of P7C3. Derivatives of P7C3 can be accessed rapidly using epoxides as lynchpins. Fluorination of the secondary alcohol provides additional analogues. Compounds are grouped as those that were less active than P7C3, equivalent to P7C3 or more active than P7C3 in the in vivo hippocampal neurogenesis assay via ICV administration. Changes from P7C3 are highlighted in red.