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. 2014 Oct 16;11(1):189–195. doi: 10.3892/mmr.2014.2683

Figure 5.

Figure 5

LAC increased cisplatin-induced endoplasmic reticulum stress-associated apoptosis in HeLa human cervical cancer cells. (A) HeLa cells were treated with cisplatin (5 μg/ml) and/or LAC (10 μM) for 12 h. Western blot analysis of grp78, CHOP, caspase-4, cleaved caspase-4, caspase-3 and cleaved caspase-3. (B) Quantitation of the protein levels. Data are presented as the mean ± standard deviation, n=3. *P<0.05 vs. control, #P<0.05 vs. cisplatin. LAC, lactacystin; grp78, glucose-regulated protein-78; CHOP, 153/C/EBP homology protein.