Figure 3.

Plasma glucose and insulin excursions in normal rats infused intravenously with glucose-dependent insulinotropic peptide (GIP) analogue peptides at 10, 30 and 100 pmol/kg/min during an intravenous glucose tolerance test (IVGTT). Effects of AC163794 on glucose (A) and insulin (C) excursions. Effects of GIP on glucose (B) and insulin (D) excursions. Insets in graphs A–D represent calculated AUC for specific peptide and specific excursion curves. (E) Calculated slope of pancreatic function curve from experiments presented in A–D. (F) Duration of insulinotropic action of AC163794 and [d-Ala²]GIP(1–42) administered as a single bolus 120 min prior to a glucose challenge (IVGTT). Data are presented as mean ± SEM. *p < 0.05 versus vehicle control (n = 6–9 control group and n = 4–6 peptide-treated groups).