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. 2013 Dec 22;74(6):643–656. doi: 10.1002/dneu.22162

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© The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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At E10.5, the development of the olfactory epithelium is not dependent on N-myc. (A) The expression of N-myc is completely missing in the olfactory epithelium of E10.5 N-myc mutants, whereas the generation of Hes5⁺ stem-like progenitors and Ngn1⁺ neuronal precursors are not different between both genotypes. The generation of Lhx2⁺, HuC/D⁺, and Tuj1⁺ post-mitotic neurons are not different between mutants and controls. The onset of Lhx2 expression is indicated in the insets. (B,C) N-myc deficiency did not alter the number of HuC/D⁺ post-mitotic neurons (B) or proliferation, indicated by pHH3⁺ staining (C). Statistical analysis of the cell counts in comparison to the total cell number in E10.5 control embryos (n = 5) and N-myc^−/− animals (n = 4) (HuC/D p = 0.5296, pHH3 p = 0.9104). Error bars represent ±SEM, Student's t test. Scale bars: 100 µm.