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. Author manuscript; available in PMC: 2015 Sep 29.
Published in final edited form as: Dev Cell. 2014 Sep 29;30(6):717–730. doi: 10.1016/j.devcel.2014.08.003

Figure 1.

Figure 1

Nanometer (nm) scale map of CCAN protein positions along the sister kinetochore axis relative to the KMN network proteins in human kinetochores at metaphase. The map was constructed from Delta measurements relative to Ndc80/Hec1(9G3) (Table S1 and Figures S1-S2). Scale on the far-left is set equal to zero at the position of the N-terminus of CENP-I centroid. Positive values are outward (towards the spindle microtubules), while negative values are inward (towards the centromere interior). Colored boxes indicate kinetochore proteins. Black dots indicate the mean Delta values that have been corrected for kinetochore tilt (Wan et al., 2009). The S.D. was typically 3-7 nm and, n > = 100 kinetochores averaged (Table S1). *Mean values obtained from Wan et al., 2009 and Varma et al., 2013.