Figure 1. Mapping sequence conservation of GH-M74a onto the surface of NiV-G.

NiV-G surface is coloured according to residue conservation with GH-M74a: red, conserved; maroon, similar; white, no sequence conservation. EphrinB2 residues 107–127 are represented as sticks. Although NiV-G shares relatively low sequence conservation with GhV-G (approximately 25%), it shares greater sequence conservation (45%) in residues that make up the receptor-binding site (calculation performed with PISA EBI server).