Figure 2.

Lxn potentiates cytotoxicity of radiation and chemotherapy drug. (a) Lxn increases radiation sensitivity of FDC-P1 cells and inhibits their growth in a dose-dependent manner. FDC-P1 cells transduced with TAP-Lxn or TAP vector were treated with different doses of radiation (3 or 6.5 Gy). (b) Lxn enhances cytotoxicity of chemotherapy drug. FDC-P1 cells transduced with TAP-Lxn or TAP vector were treated with different doses of VP-16 (20 or 30 μg/ml). Cell growth was measured by trypan blue cell count at indicated time points for 9 days. The cell number was represented by log scale. Three independent experiments were performed and the data were presented by the average±standard deviation (S.D.). P-values at each time point were indicated in the text