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. 2014 Oct 23;5(10):e1493. doi: 10.1038/cddis.2014.443

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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Lxn sensitizes FDC-P1 cells to radiation-induced cell-cycle arrest. Lxn enhances the radiation-induced cell-cycle arrest at G2/M phase and blocks the entry of G1 and S phases. TAP-Lxn or TAP-transfected FDC-P1 cells were treated with 6.5 Gy irradiation and the cell-cycle progression was analyzed by BrdU and 7AAD staining and flow cytometry at indicated time points. The representative flow cytometry profile out of three independent experiments was shown in (a) and quantification of different phases of the cell cycle (G0/G1, S and G2/M phases) was shown in (b)