Table 4. Predictors of clinical feature change in stable-state.
| Stable-state COPD (n = 18) | ||||||||
| Cox-2 expression levels | IL-1beta expression levels | RelB expression levels | IL-8 expression levels | |||||
| Clinical features | ß (95% CI) | p-value | ß (95% CI) | p-value | ß (95% CI) | p-value | ß (95% CI) | p-value |
| Systolic BP | −637.13 (−1839.06–564.79) | 0.27 | 48.89 (−2856.79–2954.56) | 0.97 | −66325.7 (−193597–60945.40) | 0.28 | −8410.48 (−16147.2–−673.76) | 0.036* |
| Diastolic BP | −1173.04 (−2117.53–−228.56) | 0.019* | −391.22 (−3170.54–2388.10) | 0.76 | −70756.5 (−191298–49784.85) | 0.22 | −7471.46 (−15178.5–235.53) | 0.056 |
| pH | 2.85 (−0.64–6.33) | 0.086 | 8.24 (1.35–15.13) | 0.029* | 182.37 (−357.62–722.36) | 0.40 | 28.54 (−6.07–63.15) | 0.084 |
| PCO2 (mmHg) | −474.44 (−861.41–−87.47) | 0.027* | −593.12 (−2343.89–1157.64) | 0.40 | −15073.0 (−98917.2–68771.15) | 0.64 | −1125.91 (−8586.88–6335.06) | 0.70 |
| cfPWV (m/s) | −634.31 (−1006.47–−262.14) | 0.0030* | −807.59 (−1798.15–182.97) | 0.10 | −10424.8 (−62823.5–41973.93) | 0.67 | −557.57 (−4426.40–3311.26) | 0.76 |
| MAP (mmHg) | −1445.68 (−2228.01–−663.36) | 0.0020* | −616.78 (−3197.05–1963.49) | 0.60 | −61331.8 (−172971–50307.08) | 0.25 | −5757.05 (−13787.5–2273.42) | 0.14 |
| Aix % | −931.72 (−1859.35–−4.09) | 0.049* | −546.46 (−2782.59–1689.67) | 0.59 | −37079.5 (−138077–63918.39) | 0.43 | −1724.41 (−9533.71–6084.89) | 0.63 |
| Cholesterol (mmol/L) | −62.21 (−119.63–−4.80) | 0.036* | −65.24 (−282.03–151.55) | 0.52 | 86.86 (−8457.91–8631.63) | 0.98 | −302.84 (−1043.82–438.15) | 0.38 |
| LDL (mmol/L) | −61.38 (−117.57–−5.19) | 0.035* | −85.14 (−294.24–123.95) | 0.39 | 1469.95 (−6853.37–9793.26) | 0.70 | −319.33 (−1042.00–403.34) | 0.35 |
| WBC (10∧9/L) | 85.65 (−54.29–225.59) | 0.21 | 504.49 (186.88–822.10) | 0.0050* | 3843.09 (−12921.6–20607.79) | 0.62 | 913.43 (−368.64–2195.49) | 0.15 |
| RBC diameter width (cV) | 44.43 (−136.38–225.24) | 0.60 | 270.73 (−259.38–800.83) | 0.29 | 8895.13 (−10807.2–28597.48) | 0.34 | 1690.40 (386.50–2994.31) | 0.016* |
| Abs. neutrophil (10∧9/L) | 85.84 (−51.73–223.41) | 0.20 | 470.02 (138.86–801.18) | 0.010* | 2751.54 (−13865.3–19368.40) | 0.72 | 1021.97 (−200.52–2244.47) | 0.093 |
| Abs. basophil (10∧9/L) | −1.23 (−4.08–1.62) | 0.36 | −2.48 (−11.38–6.43) | 0.55 | −111.46 (−435.83–212.92) | 0.47 | −27.49 (−48.50–−6.48) | 0.015* |
Linear regression models were used to estimate predictors of change in clinical features and were adjusted for age, sex, body mass index, and smoking pack-years. Inflammatory markers were used as independent variables to predict changes in all clinical features of patients. ß represents the change in a clinical feature associated with a one-unit change in biomarker expression.
*Denotes statistical significance.
MAP: mean arterial pressure.