Table 6. 26 pathways were related to immune and diseases in all pathways.
KEGG Pathway | Pathway Hierarchy 2 | Target gene of different expression miRNA |
Toll-like receptor signaling pathway | Immune system | JNK, TLR5, TBK1 |
Hepatitis C | Infectious diseases: Viral | JNK, TBK1, LDLR |
Salmonella infection | Infectious diseases: Bacterial | JNK, TLR5 |
Fc epsilon RI signaling pathway | Immune system | JNK, FYN |
Tuberculosis | Infectious diseases: Bacterial | JNK, PLK3, CTSS |
Influenza A | Infectious diseases: Viral | JNK, DNAJB1, TBK1 |
Measles | Infectious diseases: Viral | FYN, TBK1 |
MAPK signaling pathway | Signal transduction | JNK, MKP |
Toxoplasmosis | Infectious diseases: Parasitic | JNK, LDLR |
Chemokine signaling pathway | Immune system | CCR7, ADCY7, DOCK2 |
HTLV-I infection | Infectious diseases: Viral | JNK, ADCY7, SLC2A1 |
Herpes simplex infection | Infectious diseases: Viral | JNK, TBK1 |
Fc gamma R-mediated phagocytosis | Immune system | DOCK2 |
Prion diseases | Neurodegenerative diseases | FYN |
Viral myocarditis | Cardiovascular diseases | FYN |
Pathways in cancer | Cancers: Overview | JNK, SLC2A1 |
Transcriptional misregulation in cancer | Cancers: Overview | CCR7 |
Type II diabetes mellitus | Endocrine and metabolic diseases | JNK |
Cytokine-cytokine receptor interaction | Signaling molecules and interaction | CCR7, TNFSF12 |
Antigen processing and presentation | Immune system | CTSS |
Pertussis | Infectious diseases: Bacterial | JNK |
Natural killer cell mediated cytotoxicity | Immune system | FYN |
T cell receptor signaling pathway | Immune system | FYN |
Chagas disease | Infectious diseases: Parasitic | JNK |
Staphylococcus aureus infection | Infectious diseases: Bacterial | CFB |
Complement and coagulation cascades | Immune system | CFB |
List of gene abbreviations: JNK: c-Jun N-terminal kinase, TLR5: toll-like receptor 5, TBK1: TANK-binding kinase 1, LDLR: low-density lipoprotein receptor, FYN: tyrosine-protein kinase Fyn, CTSS: cathepsin S, PLK3: polo-like kinase 3, DNAJB1: DnaJ homolog subfamily B member 1, MKP: dual specificity MAP kinase phosphatase, DOCK2: dedicator of cytokinesis protein 2, ADCY7: adenylate cyclase 7, SLC2A1: MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1, CCR7: C-C chemokine receptor type 7, TNFSF12: tumor necrosis factor ligand superfamily member 12, CFB: component factor B.