Table 2. MIC of antifungals alone and with increasing concentrations of OligoG (2, 6, 10%) for a range of Aspergillus spp.
MIC (mg/L) at indicated OligoG concn (%) | ||||||||||||||||||||
Nystatin | Amphotericin B | Miconazole | Voriconazole | Terbinafine | ||||||||||||||||
Isolate | 0 | 2 | 6 | 10 | 0 | 2 | 6 | 10 | 0 | 2 | 6 | 10 | 0 | 2 | 6 | 10 | 0 | 2 | 6 | 10 |
A. niger CCUG 18919 | 8 | 4 | 2 | 0.5 | 0.188 | 0.188 | 0.094 | 0.047 | 1 | 0.5 | 0.25 | 0.25 | 0.25 | 0.063 | <0.03 | <0.03 | 0.5 | 0.25 | 0.063 | 0.125 |
A. fumigatus CCUG 17460 | 8 | 8 | 4 | 2 | 0.75 | 0.375 | 0.375 | 0.188 | 4 | 2 | 2 | 2 | 0.125 | 0.125 | 0.063 | <0.03 | 4 | 4 | 4 | 2 |
A. flavus CCUG 28296 | 8 | 8 | 4 | 2 | 0.75 | 0.375 | 0.375 | 0.188 | 1 | 0.25 | 0.25 | 0.25 | 0.063 | 0.063 | <0.03 | <0.03 | 0.125 | 0.063 | <0.03 | <0.03 |
Bold numbers indicate a Fractional Inhibitory Concentration Index (FICI)≤0.5; indicative of synergy [25].