Table 3. MIC of antifungals alone and with increasing concentrations of OligoG (2, 6, 10%) for a range of Candida spp.
MIC (mg/L) at indicated OligoG concn (%) | ||||||||||||
Nystatin | Fluconazole* | Terbinafine | ||||||||||
Isolate | 0 | 2 | 6 | 10 | 0 | 2 | 6 | 10 | 0 | 2 | 6 | 10 |
C. albicans CCUG 39343 | 8 | 8 | 4 | 2 | 16 | 16 | 8 | 4 | >32 | >32 | >32 | >32 |
C. parapsilosis ATCC 22019T | 8 | 4 | 1 | 0.5 | 2 | 2 | 0.5 | 0.25 | 2 | 2 | 2 | 2 |
C. krusei 141/03 | 8 | 4 | 2 | 2 | 128 | 64 | 64 | 64 | >32 | >32 | >32 | >32 |
C. krusei 249/03(2) | 8 | 8 | 8 | 4 | 8 | 4 | 2 | 1 | 4 | 4 | 8 | 4 |
C. lusitaniae 994/01(2) | 8 | 8 | 2 | 1 | 0.5 | 0.25 | <0.13 | <0.13 | 8 | 4 | 4 | 2 |
C. tropicalis 12 | 8 | 8 | 4 | 4 | 1 | 1 | <0.13 | <0.13 | >32 | 16 | >32 | 32 |
C. tropicalis 519468 | 16 | 8 | 4 | 2 | 1 | 1 | 0.25 | <0.13 | >32 | >32 | >32 | >32 |
C. tropicalis 250/03 | 8 | 4 | 2 | 1 | 8 | 4 | 2 | 2 | >32 | >32 | >32 | >32 |
C. tropicalis T2.2 | 8 | 8 | 4 | 2 | 0.5 | 0.25 | <0.13 | <0.13 | >32 | >32 | >32 | 32 |
*MIC values of fluconazole for C. tropicalis strains (519468 and T2.2) were determined at 36 h.
Bold numbers indicate a Fractional Inhibitory Concentration Index (FICI)≤0.5; indicative of synergy [25].