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. 2014 Nov 19;9(11):e113057. doi: 10.1371/journal.pone.0113057

Table 4. Multivariate analysis of the determinants of capsaicin cough hypersensitivity.

Variables C5≤62.5 µmol (No., %) C5>62.5 µmol (No., %) Multivariable regression model
OR 95%CI P
Sex
 Male 11 (21.2) 41 (49.4%) - Reference -
 Female 41 (78.8%) 42 (50.6%) 3.25 1.35-7.83 <0.01
HRCT total score
 ≤6 16 (30.8%) 50 (60.2%) - Reference -
 7-12 28 (53.8%) 26 (31.3%) 2.57 1.07-6.17 0.04
 ≥13 8 (15.4%) 7 (8.4%) 2.32 0.66-8.17 0.19
BSI
 0-4 11 (21.2%) 41 (49.4%) - Reference -
 5-8 24 (46.2%) 25 (30.1%) 4.05 1.48-11.06 <0.01
 ≥9 17 (32.7%) 17 (20.5%) 4.38 1.48-12.93 <0.01

Categorical data were expressed as number (percentage) and compared with chi-square test.

Data in boldface indicated statistical significance.

In multivariate analysis, settings of the covariates were as follows: Sex: 0 for female, 1 for males; duration of cough: 0 for less than 5 years, 1 for 5 to 10 years, 2 for greater than 10 years; HRCT score: 0 for 6 or less, 1 for greater than 7 and less than 13, 2 for 13 or greater; bronchiectasis severity index: 0 for 4 or less, 1 for 5 to 8, 2 for 9 or greater; 24-hour sputum volume: 0 for 10 ml or less, 1 for greater than 10 and less than 30 ml, 2 for 30 ml or greater; cough symptom score: 0 for 5 or less, 1 for greater than 5; sputum bacteriology: 0 for commensals, 1 for Pseudomonas aeruginosa, 2 for other PPMs.