Table 1. Genotype and minor allele frequency of the IL1RL1 and IL33 analyzed polymorphisms in biopsy-proven GCA patients and controls from Spain.
| Genotype, N (%) | Allele test | Recessive model | |||||||||||
| SNP | Locus | 1/2 | Subgroup (N) | 1/1 | 1/2 | 2/2 | MAF (%) | P-value | P FDR * | OR [CI 95%]** | P-value | P FDR * | OR [CI 95%]** |
| rs2310173 | IL1RL1 | T/G | Controls (n = 1972) | 458 (23.23) | 958 (48.58) | 556 (28.19) | 47.52 | ||||||
| GCA (n = 863) | 205 (23.75) | 395 (45.77) | 263 (30.48) | 46.64 | 0.5434 | 0.9304 | 0.97 [0.86–1.08] | 0.7594 | 0.9458 | 1.03 [0.85–1.24] | |||
| rs13015714 | IL1RL1 | G/T | Controls (n = 1944) | 138 (7.10) | 729 (37.50) | 1077 (55.40) | 25.85 | ||||||
| GCA (n = 868) | 61 (7.03) | 329 (37.90) | 478 (55.07) | 25.98 | 0.9178 | 0.9304 | 1.01 [0.88–1.15] | 0.9458 | 0.9458 | 0.98 [0.72–1.35] | |||
| rs2058660 | IL1RL1 | G/A | Controls (n = 2005) | 141 (7.03) | 767 (38.25) | 1097 (54.71) | 26.16 | ||||||
| GCA (n = 858) | 52 (6.06) | 343 (39.98) | 463 (53.96) | 26.05 | 0.9304 | 0.9304 | 0.99 [0.87–1.13] | 0.3425 | 0.6850 | 0.85 [0.61–1.19] | |||
| rs3939286 | IL33 | T/C | Controls (n = 1983) | 190 (9.58) | 826 (41.65) | 967 (48.76) | 30.41 | ||||||
| GCA (n = 862) | 80 (9.28) | 362 (42.00) | 420 (48.72) | 30.28 | 0.9219 | 0.9304 | 0.99 [0.88–1.12] | 0.8014 | 0.9458 | 0.97 [0.73–1.27] | |||
| rs7025417 | IL33 | C/T | Controls (n = 1969) | 72 (3.66) | 533 (27.07) | 1364 (69.27) | 17.19 | ||||||
| GCA (n = 871) | 15 (1.72) | 237 (27.21) | 619 (71.07) | 15.33 | 0.0818 | 0.4907 | 0.87 [0.75–1.02] | 7.04E-03 | 0.0423 | 0.46 [0.26–0.81] | |||
| rs7044343 | IL33 | C/T | Controls (n = 1957) | 220 (11.24) | 865 (44.20) | 872 (44.56) | 33.34 | ||||||
| GCA (n = 864) | 114 (13.19) | 377 (43.63) | 373 (43.17) | 35.01 | 0.2218 | 0.6655 | 1.08 [0.96–1.21] | 0.1393 | 0.4180 | 1.20 [0.94–1.53] | |||
*Benjamini and Hochberg step-up false discovery rate control. ** Odds ratio for the minor allele or genotype.
MAF, minor allele frequency; GCA, giant cell arteritis.