Table 2. Replication and pooled analysis of the tested IL33 genetic variants in European biopsy-proven GCA patients and controls.
| Genotype, N (%) | Allele test | Recessive model | |||||||||
| SNP | 1/2 | Subgroup (N) | 1/1 | 1/2 | 2/2 | MAF (%) | P-value | OR [CI 95%]* | P-value | OR [CI 95%]* | |
| Germany | rs3939286 | T/C | Controls (n = 427) | 28 (6.56) | 147 (34.43) | 252 (59.02) | 23.77 | ||||
| GCA (n = 102) | 3 (2.94) | 37 (36.27) | 62 (60.78) | 21.08 | 0.4135 | 0.86 [0.59–1.24] | 0.1741 | 0.43 [0.13–1.45] | |||
| rs7025417 | C/T | Controls (n = 430) | 28 (6.51) | 149 (34.65) | 253 (58.84) | 23.84 | |||||
| GCA (n = 101) | 3 (2.97) | 41 (40.59) | 57 (56.44) | 23.27 | 0.8640 | 0.97 [0.67–1.39] | 0.1833 | 0.44 [0.13–1.48] | |||
| rs7044343 | C/T | Controls (n = 436) | 67 (15.37) | 201 (46.10) | 168 (38.53) | 38.42 | |||||
| GCA (n = 101) | 16 (15.84) | 51 (50.50) | 34 (33.66) | 41.09 | 0.4828 | 1.12 [0.82–1.53] | 0.9054 | 1.04 [0.57–1.88] | |||
| Italy | rs3939286 | T/C | Controls (n = 1109) | 94 (8.48) | 437 (39.40) | 578 (52.12) | 28.18 | ||||
| GCA (n = 251) | 13 (5.18) | 82 (32.67) | 156 (62.15) | 21.51 | 2.37E-03 | 0.70 [0.55–0.88] | 0.0830 | 0.59 [0.32–1.07] | |||
| rs7025417 | C/T | Controls (n = 1106) | 29 (2.62) | 282 (25.50) | 795 (71.88) | 15.37 | |||||
| GCA (n = 255) | 4 (1.57) | 59 (23.14) | 192 (75.29) | 13.14 | 0.2023 | 0.83 [0.63–1.10] | 0.3295 | 0.59 [0.21–1.70] | |||
| rs7044343 | C/T | Controls (n = 1116) | 188 (16.85) | 520 (46.59) | 408 (36.56) | 40.14 | |||||
| GCA (n = 252) | 46 (18.25) | 116 (46.03) | 90 (35.71) | 41.27 | 0.6415 | 1.05 [0.86–1.28] | 0.5920 | 1.10 [0.77–1.57] | |||
| Norway | rs3939286 | T/C | Controls (n = 271) | 15 (5.54) | 100 (36.90) | 156 (57.56) | 23.99 | ||||
| GCA (n = 108) | 6 (5.56) | 45 (41.67) | 57 (52.78) | 26.39 | 0.4883 | 1.14 [0.79–1.63] | 0.9937 | 1.00 [0.38–2.66] | |||
| rs7025417 | C/T | Controls (n = 267) | 12 (4.49) | 91 (34.08) | 164 (61.42) | 21.54 | |||||
| GCA (n = 111) | 5 (4.50) | 36 (32.43) | 70 (63.06) | 20.72 | 0.8032 | 0.95 [0.65–1.40] | 0.9965 | 1.00 [0.34–2.92] | |||
| rs7044343 | C/T | Controls (n = 273) | 43 (15.75) | 135 (49.45) | 95 (34.80) | 40.48 | |||||
| GCA (n = 108) | 14 (12.96) | 45 (41.67) | 49 (45.37) | 33.80 | 0.0878 | 0.75 [0.54–1.04] | 0.4924 | 0.80 [0.42–1.53] | |||
| Meta-analysis | rs3939286 | T/C | Controls (n = 3790) | 327 (8.63) | 1510 (39.84) | 1953 (51.53) | 28.55 | ||||
| GCA (n = 1323) | 102 (7.71) | 526 (39.76) | 695 (52.53) | 27.59 | 0.1358 | 0.93 [0.84–1.02] | 0.2036 | 0.85 [0.67–1.08] | |||
| rs7025417 | C/T | Controls (n = 3772) | 141 (3.74) | 1055 (27.97) | 2576 (68.29) | 17.72 | |||||
| GCA (n = 1338) | 27 (2.02) | 373 (27.88) | 938 (70.10) | 15.96 | 0.0408 | 0.88 [0.78–0.99] | 3.40E-03 | 0.53 [0.35–0.80] | |||
| rs7044343 | C/T | Controls (n = 3782) | 518 (13.70) | 1721 (45.51) | 1543 (40.80) | 36.45 | |||||
| GCA (n = 1325) | 190 (14.34) | 589 (44.45) | 546 (41.21) | 36.57 | 0.3747 | 1.04 [0.95–1.14] | 0.2447 | 1.12 [0.93–1.34] | |||
*Odds ratio for the minor allele or genotype.
MAF, minor allele frequency; GCA, giant cell arteritis.